Justin Taylor
Associate Professor, Medicine
Miller School of Medicine Member, Sylvester Comprehensive Cancer Center
jxt1091@miami.edu
Justin Taylor, MD, is a physician-scientist devoted to improving outcomes for patients with hematologic malignancies. He is a tenure-track Associate Professor and member of the Translational and Clinical Oncology program at the University of Miami Sylvester Comprehensive Cancer Center. The Taylor lab studies the role of recurrent mutations in hematologic malignancies and how to target them with novel therapeutics using animal modeling, molecular biology and single-cell genomic techniques. The central focus of the lab is on understanding how alterations in nuclear export function due to mutations or overexpression of XPO1 contribute to oncogenesis. The lab uses molecular biology, genomics, proteomics and mouse modeling to determine the mechanisms and potential targetable weaknesses of these genetic alterations. They also study how patients may become resistant to targeted therapies. Specifically, they discovered and are studying recurrent mutations in BTK kinase domain that drive resistance to noncovalent and covalent BTK inhibitors. Dr. Taylor also holds a faculty position in the Department of Medicine, Division of Hematology where he sees patients with hematologic malignancies.
Keywords: cancer, blood, bone marrow, novel therapeutics, therapy resistance
